The HCM Registry

Novel Predictors of Outcome in Hypertrophic Cardiomyopathy

What is Hypertrophic Cardiomyopathy (HCM)?

Hypertrophic Cardiomyopathy (HCM) is a condition, mostly inherited, in which the heart muscle becomes thickened.

People  with  this  condition  usually  do  not  have  symptoms. However, in some people with this condition, there is a risk of developing complications such as failure of the heart to pump blood and sudden death.

Currently it is difficult to say why some people develop these complications and others do not.

How Do We Study Hypertrophic Cardiomyopathy?

We use Magnetic Resonance Imaging (MRI) of the heart.

Below are videos of two beating hearts taken using an MRI scanner. The muscle in the heart with Hypertrophic Cardiomyopathy is thicker compared to the normal heart.

Normal Heart

Heart with Hypertrophic Cardiomyopathy

Heart Muscle Thickness Comparison

Normal heart muscle thickness
Thickened heart muscle
People enrolled 2750
The HCMR study is well under way, with the first participant enrolled in April 2014 at research site 001.  There are now 44 active sites; 22 sites in North America and 22 sites in Europe. The study is now following up the 2750 patients that were enrolled and is no longer recruiting.

The Health Research Authority’s National Research Ethics Service Committee – South Central Oxford A, has reviewed and approved this research study and website

HRA NRES Research Ethics Reference Number 14/SC/0190

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